High risk groups 1,2

  • Children 1–12 years with a diagnosis of asthma
  • Children 1–12 years who are exposed to asthma triggers. See Table 2.

Urgent referral

  • For an acute asthmatic episode see the Primary Clinical Care Manual
  • All infants < 12 months with a clinically significant wheeze should be reviewed urgently by an MO/NP

Special considerations

  • A prior diagnosis of asthma should be corroborated by documented evidence

1. What is asthma? 1–4

  • See Asthma (adults and children > 12)

2. Diagnosis of asthma in children 1–12 years 1–4

  • In children, asthma diagnosis is based primarily on:
    • history of recurrent or persistent wheeze
    • presence of allergies or family history of asthma and allergies
    • absence of physical findings that suggest an alternative diagnosis
    • tests that support the diagnosis
    • a consistent clinical response to an inhaled bronchodilator or preventer
  • Diagnosing children with asthma is difficult because:
    • spirometry can be difficult
    • respiratory symptoms such as cough and wheeze are common
    • those who respond to inhalers often do not have asthma when older
  • Table 1. outlines findings that increase or decrease the likelihood of asthma

Table 1. Findings that increase or decrease the probability of asthma in children 1–12 years

Asthma more likely

Asthma less likely

More than one of these symptoms

  • Wheeze
  • Difficulty breathing
  • Feelings of tightness in the chest
  • Cough

Any of

  • Symptoms only occur when child has a cold, but not between colds
  • Isolated cough in the absence of wheeze or difficulty breathing
  • History of moist cough
  • Dizziness, light-headedness or peripheral tingling
  • Repeatedly normal physical examination of chest when symptomatic
  • Normal spirometry when symptomatic (children old enough to perform spirometry)
  • No response to a trial of asthma treatment
  • Clinical features that suggest an alternative diagnosis

AND

Any of

  • Symptoms recur frequently. See Table 3.
  • Symptoms worse at night and in the early
    morning
  • Symptoms triggered by exercise, exposure to pets, cold air, damp air, emotions, laughing
  • Symptoms occur when child doesn’t have a cold
  • History of allergies e.g. hay fever, atopic dermatitis
  • Family history of allergies
  • Family history of asthma
  • Widespread wheeze heard on auscultation
  • Symptoms respond to treatment trial of reliever, with or without a preventer
  • Lung function measured by spirometry increases in response to rapid-acting bronchodilator
  • Lung function measured by spirometry increases in response to a treatment trial with inhaled corticosteroid (where indicated)

Adapted with permission from the Australian Asthma Handbook, Version 2.2 © 2022 National Asthma Council Australia.

  • Alternative causes of a recurrent wheeze in children may include:
    • lower (infants) and upper (older children) viral respiratory tract infections
    • aspirate (reflux)
    • inhaled foreign body
    • rhino-sinusitis
    • tuberculosis
    • cystic fibrosis
    • bronchopulmonary dysplasia
    • congenital malformation of the airways
    • immune deficiency
    • congenital heart disease
  • Flowchart 1. illustrates the steps to confirm an asthma diagnosis in children under 12

Flowchart 1. Steps to diagnosing asthma in children 1–12 years

Steps to diagnosing asthma in children 1–12 years

Adapted with permission from the Australian Asthma Handbook, Version 2.1. © 2020 National Asthma Council Australia.

3. Management of children 1–12 years with asthma 1–4,6,7

  • The goals of managing asthma are to:
    • engage the child and parent/carer to identify asthma management goals
    • minimise impact of asthma on quality of life
    • optimise asthma symptom control with minimal medicines
    • minimise risk of exacerbations and loss of lung function
    • minimise adverse effects of treatment
    • identifying and managing comorbid conditions including:
      • hay fever; common in children and associated with poor asthma control
      • Overweight and obesity (child)
  1. Support child self-management 8
    • See Lifestyle modifications with particular attention to Smoking cessation and Diet and nutrition
    • Provide culturally appropriate resources about asthma and support services. See Resource 1.
    • In partnership develop an asthma action plan (Resource 2.) identifying:
      • asthma triggers. See Table 2.
      • symptoms that indicate asthma is worsening
      • actions to take when symptoms worsen
      • when and how to use medicines and correct inhaler use. See Resource 3.
      • doses and frequencies of regular medicines
      • how to adjust treatment in response to particular signs and symptoms
      • when to start oral corticosteroids
      • when and how to seek urgent medical help
    • At each visit the asthma action plan should be reviewed and adjusted as required
    • Patients who accept their asthma symptoms as normal, require added support to show that symptoms and quality of life will improve with correct medicine use, lifestyle modification and regular monitoring. See Resource 1.
    • Encourage the patient to identify barriers to adequate lifestyle modification and
      medical adherence and create goals to overcome those barriers. See Engaging our patients
  2. Social-emotional support 3,8
    • Parents/carers of children with chronic conditions experience high levels of stress and anxiety
    • See Social-emotional wellbeing

Table 2. Summary of asthma triggers for children 1–12 years

Avoidable triggers

Unavoidable triggers

Always avoid

Do not avoid

  • Cigarette smoke
  • Exercise
  • Laughter

Avoid or reduce if possible

Manage

Allergens

  • Animals
  • Cockroaches
  • House dust mite
  • Moulds
  • Allergens at school/daycare
  • Pollens

Airborne/environmental irritants

  • Cold/dry air
  • Fuel combustion e.g. gas heaters
  • Home renovation materials
  • Household aerosols
  • Moulds (airborne)
  • Irritants at school/daycare
  • Outdoor industrial and traffic pollution
  • Perfumes/scents/incense
  • Smoke e.g. cigarettes, vapes, camp fires
  • Thunderstorms in spring and early summer (grass pollen)

Certain medicines

  • Aspirin and NSAIDs (in patients with aspirin-exacerbated respiratory disease)
  • Bee products e.g. pollen, propolis, royal jelly
  • Echinacea

Dietary triggers

  • Food chemicals/additives (if child is intolerant)
  • Thermal effects e.g. cold drinks

Respiratory tract infections

Certain medicines (requires close specialist supervision)

  • Aspirin (when given for purpose of desensitisation)
  • Anticholinesterases and cholinergic agents
  • Beta blockers

Comorbid medical conditions

  • Hay fever/rhinosinusitis
  • Gastroesophageal reflux disease
  • Nasal polyposis
  • Obesity
  • Upper airway dysfunction

Physiological and psychological changes

  • Extreme emotions
  • Hormonal changes e.g. menstrual cycle

Adapted with permission from the Australian Asthma Handbook, Version 2.1. © 2020 National Asthma Council Australia

  1. Avoiding cigarette smoke 1,3,4
    • Being subjected to cigarette smoke is a primary trigger for developing and exacerbating asthma symptoms in children
    • Be mindful of the parent/carer smoking behaviour and frequency when assessing a child's recent asthma symptom control
    • Reinforce the dangers of passive smoking, particularly in homes and cars
    • Regularly encourage the parent/carer to quit smoking. See Smoking cessation
  2. Nutrition 1,2
    • Weight reduction in overweight or obese children reduces asthma symptoms. Consider a referral to a dietitian
    • The risk of asthma exacerbations is reduced in those who have a diet high in fresh fruit and vegetables and oily fish
    • A diet high in processed foods and soft drink increases the risk of developing asthma
    • See Diet and nutrition
  3. Child asthma control
    • Ascertain the child's recent level of asthma symptom control using Table 3.
    • Recent asthma symptom control is based on symptoms over the previous 4 weeks
    • When counting the times a child uses their reliever puffer, do not include times taken before exercise

Table 3. Definition of levels of recent asthma symptom control in children 1,3

In the past 4 weeks, has the child had

Well controlled

Partly controlled

Poorly controlled

Children 6–11 years

  • Daytime symptoms >2 per week?
  • Need for reliever >2 per week?
  • Any activity limitation due to asthma?
  • Any night waking due to asthma?

None of these

1–2 of these

3 or more of these

Children 1–6 years

  • Daytime symptoms for more than a few minutes >1 per week?
  • Need for reliever >1 per week?
  • Any activity limitation due to asthma?
  • Any night waking or coughing due to asthma?

Sample questions for reviewing asthma control in children

  • How often does the child:
    • use their reliever puffer? How many puffs? How long does it last?
    • need a new prescription?
    • wheeze, become short of breath or cough?
    • wake at night due to wheezing, shortness of breath or coughing?
    • use a preventer puffer? What dose? How many puffs per day?
    • miss time from school or sport due to asthma?
    • visit a GP/hospital emergency for asthma symptoms?

4. Medicines for children 1–12 years with asthma 1,3,4

  • Use Flowchart 2. to determine optimal medicine use for the child with asthma
  • Medicines should be reviewed by the MO/NP or pharmacist according to child's response and current condition

Flowchart 2. Intervention to achieve asthma control

 Intervention to achieve asthma control

  1. rect inhaler use 3
    • Regular Inhaler and spacer use technique should be demonstrated, taught and monitored in this age group. See Resource 3.

To reduce adverse effects and increase delivery to the airways, when using inhaled medicines, children:

  • < 4 years should use a pMDI plus a spacer with face mask
  • > 4 years should use a pMDI plus spacer with a spacer mouthpiece
  • SABA should only be used at the lowest dose and frequency required if:
    • asthma symptoms occur (e.g. wheezing or breathlessness)
    • before exercise for those with known exercise induced asthma
  1. Medicine precautions in asthma 1,3,5
    • Any newly obtained medicines (prescriptions, over the counter or complimentary) should be checked for asthma trigger risk. See Table 2.
    • Sedatives are contraindicated during an acute asthma episode

Flowchart 3. Stepped approach to adjusting asthma medicine in children 1–12 years 2,3,9


Stepped approach to adjusting asthma medicine in children 1–12 years

Table 4. Medicines for children 1–12 years with asthma 1,3,4,9

SABA (reliever)

Salbutamol (pMDI) 100 microgs (1-2 puffs) inhaled PRN

Terbutaline (DPI) 500 microgs (1 puff) inhaled PRN. Only for use in children < 8 years

  • DPI inhalers (i.e. terbutaline) require correct technique to work adequately. May be an issue for younger children

*LTRA (preventer)2–12 years only

Montelukast (chewable tablet)

  • 4mg PO daily for 2–5 years of age
  • 5mg PO daily for 6–12 years of age
  • An alternative to ICS (low dose)
  • Increased risk of neuropsychiatric adverse effects

ICS (preventer)

  • Specific doses are tailored to the child's level of asthma control
  • Minimise risk of oropharyngeal candidiasis by rinsing mouth with water after use

Beclometasone dipropionate (MDI)

  • Low 50–100 microgs inhaled bd
  • High 100–200 microgs inhaled bd
  • Only use with some small volume spacers without perfect seal
  • Only for use in children > 5 years

Budesonide (DPI)

  • Low 100–200 microgs inhaled bd
  • High 200–400 microgs inhaled bd
  • DPI inhalers (i.e. terbutaline) require correct technique to work adequately. May be an issue for younger children
  • Budesonide for use in children > 5 years only

Fluticasone propionate (pMDI and DPI)

  • Low 50–100 microgs inhaled bd (max. for children < 5 years)
  • High 100–250 microgs inhaled bd

ICS–LABA (preventer 6–11 years)

  • Minimise risk of oropharyngeal candidiasis by rinsing mouth with water after use

Fluticasone propionate and salmeterol (Seretide®)

  • 50/25 microgs pMDI (2 puffs) inhaled bd
  • 100/50 microgs DPI (1 puff) inhaled bd

*See LAM and PBS for medicine indications and restrictions

  1. Medicine review 3
    • Children should be reviewed:
      • 2–4 weeks after an exacerbation OR
      • 1–3 months after an initial visit with preference given to 3 months to ascertain the medicines effectiveness to control the asthma OR
      • every 6 months
    • If a child's asthma is poorly controlled within 1–3 months step up treatment
    • If good controlis achieved for 6 months then stepdown treatment to the least
      medicine required to maintain control
    • Ongoing monitoring is necessary every 3–6 months once good control is achieved so that adjustments can be made in response to worsening symptoms or episodes of exacerbations
    • Children should be reviewed 3–6 weeks after asthma therapy has been discontinued to assess for residual symptoms
    • Overuse of SABA requires review as this is a sign of poor control

Table 5. Reviewing and adjusting asthma preventer treatment for children 1–12 years 1,3,4,9

Treatment

Review

Treatment response

Good

None

SABA

4 wkly

  • Continue SABA use
  • Review in 3–6 months
  • If asthma management factors optimal then

Step up

  • Add ICS (low dose)
  • Review in 2–4 weeks

ICS (low dose)

4 wkly

  • If asthma management factors optimal then continue treatment and review in 6 months
  • After 6 months Step down if well controlled
  • If asthma management factors optimal then

Step up

  • Increase ICS (high dose) or
  • Add montelukast to ICS (low dose)
  • Review in 2–4 weeks

ICS (high dose)

or

ICS (low dose)plus LTRA

4 wkly

  • If asthma management factors optimal then continue treatment and review in 6 months
  • After 6 months Step down if well controlled
  • If asthma management factors and inhaler technique optimal then

Refer for specialist review

5. Cycle of care

Cycle of care summary for children 1–12 years with asthma

Action

Dx

Good control

Partial control

Poor control

Height

3 mthly until 2 years of age for high risk groups otherwise as per child health check

Weight

 

As above

 

Inhaler technique

12 mthly

6 mthly

3 mthly

Spirometry

12 mthly

6 mthly

3 mthly

Social-emotional wellbeing

12 mthly

6 mthly

3 mthly

Lifestyle modification

12 mthly

6 mthly

3 mthly

Self-management education

12 mthly

6 mthly

3 mthly

Asthma action plan and asthma first aid

At each visit

Symptom review

4 wkly or when changing medicines

Medication review

MO/NP review

12 mthly

6 mthly

3 mthly

RN/IHW review

12 mthly

6 mthly

3 mthly

Specialist MO

Any uncontrolled or difficult to treat asthma

Any child under 2 years of age requiring a SABA

Influenza, pneumococcal, pertussis and covid vaccines

Recommended. See the Australian Immunisation Handbook for the schedule

Comorbidity management

Each time child is assessed for asthma control

6. References

7. Resources

  1. Asthma resources
  2. Asthma action plan and the First Aid for Asthma chart
  3. Inhaler use videos and printable instructions